Soil bacterium helps kill cancers

A bacterium found in soil is a showing promise as a way of delivering cancer drugs into tumours.

Spores of the Clostridium sporogenes bacterium can grow within tumours because there is no oxygen.

UK and Dutch scientists have been able to genetically engineer an enzyme into the bacteria to activate a cancer drug.

Experts said it would be some time before the potential benefits of the work – presented to the Society of Microbiology – were known.

The work is being presented to the society’s autumn conference at the University of York.

The spores grow only within solid tumours, such as breast, brain and prostate tumours and not in other tissue in the body, where oxygen is present.

Researchers have been investigating the possibilities of clostridium “vectors” to deliver cancer drugs for decades

This is a totally natural phenomenon, which requires no fundamental alterations and is exquisitely specific”

Professor Nigel Minton University of Nottingham

The scientists from the University of Nottingham and Maastricht University were able to genetically engineer an improved version of an enzyme into C.sporogenes.

In animal tests, a drug was also injected into the bloodstream which becomes active only when it is triggered by this enzyme.

It then destroys only the cells in its vicinity – the tumour cells.

Professor Nigel Minton, who led the research, said: “Clostridia are an ancient group of bacteria that evolved on the planet before it had an oxygen-rich atmosphere and so they thrive in low oxygen conditions.

“When Clostridia spores are injected into a cancer patient, they will only grow in oxygen-depleted environments, ie the centre of solid tumours.

“This is a totally natural phenomenon, which requires no fundamental alterations and is exquisitely specific.

“We can exploit this specificity to kill tumour cells but leave healthy tissue unscathed.”

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